Table 2. Average metal concentrations for the HPCf.

				Control (µg/g)				Treated (µg/g)
Region	Study	Method	Mn	Fe	Cu	Zn	Mn	Fe	Cu	Zn
HPCfa	Here	XRF	0.39 ± 0.03	10.45 ± 0.99	1.41 ± 0.08	13.57 ± 0.97	1.00 ± 0.19**	9.28 ± 1.17	1.39 ± 0.14	12.01 ± 1.71
	75	AAS	0.38 ± 0.04	12.40 ± 3.44	1.91 ± 0.05		0.72 ± 0.10**	19.2 ± 0.88**	2.26 ± 0.23*
	76	AAS	0.287 ± 0.002	13.55 ± 0.26	2.122 ± 0.120	16.83 ± 0.36
	77	NAAb/XRF	0.57 ± 0.17	16.42 ± 3.89	4.56 ± 0.85		2.11 ± 0.44*	14.01 ± 0.78	4.11 ± 0.35
	78c	NAA	0.21 ± 0.04	32.0 ± 9.0	4.19 ± 1.31	15.84 ± 2.78	1.10 ± 0.22**	26 ± 7	7.65 ± 0.74*	14.04 ± 1.87
	79d	NAA	0.213 ± 0.060				0.360 ± 0.167*
HPCf 1a	Here	XRF	0.36 ± 0.03	8.75± 0.82	1.34 ± 0.06	12.01± 0.94	0.98 ± 0.18**	8.14 ± 1.09	1.34 ± 0.15	11.32 ± 1.59
HPCf 2a	Here	XRF	0.41 ± 0.02	12.43 ± 0.86	1.67 ± 0.05	10.33 ± 0.99	0.98 ± 0.08**	11.84 ± 1.14	1.74 ± 0.11	9.37 ± 0.70+
	Here (7×7 µm2)	XRF					0.62 ± 0.11	8.63 ± 0.70	1.11 ± 0.15	6.88 ± 0.71
EC	49	XRF	2.0 ±0.9	30.2 ±7.5	3.5 ±0.7	17.3 ±2.9	3.0 ±2.7	23.5 ±4.0	3.9 ±0.4	17.3 ±1.7
HPCf 3e	Here	XRF	0.41 ± 0.05	9.97 ± 1.30	1.19 ± 0.16	20.27 ± 2.43	1.21 ± 0.22**	8.51 ± 1.02	1.14 ± 0.09	18.71 ± 2.56
CA3/DG	49	XRF	2.5 ±1.6	36.4 ±13.7	2.9 ±0.4	55.0 ±8.6	5.0 ±2.4	23.8 ±5.9	2.4 ±0.7	46.9 ±4.4
HPCf 4e	Here	XRF	0.42 ± 0.05	15.14 ± 1.99	1.31 ± 0.08	17.07 ± 3.38	1.26 ± 0.13**	11.01 ± 1.40**	1.27 ± 0.17	15.63 ± 1.19
	Here (7×7 µm2)	XRF					0.72 ± 0.12	10.31 ± 0.94	0.81 ± 0.17	10.97 ± 1.69
HPCf 5e	Here	XRF	0.37 ± 0.03	9.75 ± 1.60	1.27 ± 0.25	27.51 ± 4.37	1.21 ± 0.08**	7.68 ± 1.20+	1.09 ± 0.09	23.45 ± 1.82
	Here (7×7 µm2)	XRF					0.63 ± 0.10	6.36 ± 0.88	0.95 ± 0.34	16.81 ± 1.99

⁺p < 0.1,

^*p < 0.5,

^**p < 0.01 as compared to control

^an = 2/4 animals (control/treated).

^bNAA used to measure Mn content; XRF was used for Fe and Cu measurements.

^cTreated rodents exposed to 20 mg Mn/mL drinking water from birth to 120 days.

^dTreated rodent exposed to 1 mg Mn/mL drinking water from birth to 130 days.

^en = 2/3 animals (control/treated).