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. 2014 Jan 13;211(1):15–28. doi: 10.1084/jem.20131080

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© 2014 Li et al.

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Figure 3. — TSC2 negatively regulates COX-2 expression and prostaglandin production in a xenograft tumor model of ELT3 cells. Female CB17-scid mice were inoculated with ELT3-V3 cells (TSC⁻, vector addback) or TSC2 addback (TSC2⁺) ELT3-T3 cells subcutaneously. (a and d) Immunoblot analysis shows levels of phospho-S6 (S235/236), COX-2, and PTGIS in xenograft tumors of ELT3 cells. Levels of PGE₂ in xenograft tumors (b), urinary levels of PGE₂ (c), and 6-keto-PGF_1α (e) were normalized to creatinine levels in mice bearing xenograft tumors (n = 9; ELISA). Results are representative of five to nine mice per group. *, P < 0.05; ***, P < 0.001; Student’s t test.