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. 2014 Jan 13;211(1):137–151. doi: 10.1084/jem.20131019

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© 2014 Chang et al.

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Figure 5. — TRAF3 is required for T_FR cell induction. (A and B) WT-R26^YFP and Traf3^Treg-KO-R26^YFP (KO) mice (8 wk old) were immunized with SRBCs, and 10 d later, the frequency of T_FR cells (CXCR5⁺PD-1⁺YFP⁺CD4⁺) in the spleen was assessed by flow cytometry. Data are presented as a representative plot (A) and mean ± SD (B) based on eight WT and nine KO mice. (C and D) Mice were immunized as in A and B, and the frequency and absolute number of T_FR cells was assessed by flow cytometry based on surface staining of CXCR5 and intracellular staining of Bcl-6 within Foxp3⁺CD4⁺ T_reg cells. Data are presented as a representative plot (C) and mean ± SD (D) based on eight WT and nine KO mice. (A–D) Data are representative of three to four independent experiments.*, P < 0.05; and **, P < 0.01.