Table 1.
Baseline parameters for TIMI II patients as a function of unbound free fatty acid quartiles.
| Number in quartiles | Quartile1 458 | Quartile2 458 | Quartile3 459 | Quartile4 459 | p Value |
|---|---|---|---|---|---|
| Unbound free fatty acids (nmol/L) | 1.9 (0.09 – 2.6) | 3.2 (2.6 – 3.9) | 4.9 (3.9 – 6.4) | 10.2 (6.46 – 523) | |
| Age (years) | 53.9 | 53.8 | 55.3 | 55.4 | 0.008 |
| Men | 398(87%) | 389(85%) | 344(75%) | 372(81%) | <0.0001 |
| White | 398(87%) | 398(87%) | 409(89%) | 398(87%) | 0.62 |
| Body Mass Index (kg/m2) | 27 (15-40) | 27 (18-46) | 27 (16-54) | 27 (17-54) | 0.55 |
| Diastolic blood pressure (mm Hg) | 81 (42 -130) | 81 (50 -110) | 80.2 (40-120) | 78.2 (40-118) | 0.053 |
| Systolic blood pressure (mm Hg) | 130 (56 -180) | 130 (60-183) | 129 (80-210) | 126 (50 -190) | 0.044 |
| Creatine Kinase (IU/L) | 105 (5 -1760) | 104 (12 -3590) | 94 (11 -4422) | 99 (11-3654) | 0.080 |
| Diabetes mellitus | 41(9%) | 37(8%) | 73(16%) | 78(17%) | <0.0001 |
| Prior MI | 60(13%) | 64(14%) | 69(15%) | 73(16%) | 0.50 |
| Prior hypertension | 174(38%) | 156(34%) | 188(41%) | 179(39%) | 0.20 |
| β blocker within 24 hours | 87(19%) | 87(19%) | 78(17%) | 73(16%) | 0.68 |
Values for ordinal parameters are percent and p values were calculated by χ2. Continuous parameters are median values and intra-quartile ranges. p values were determined by the Kruskal-Wallis test. Ages were grouped to protect confidentiality and are proportional to the grouped mean for each quartile. Baseline creatine kinase levels were elevated above the upper limit of normal in fewer than 20 % of patients. Mean time from chest pain symptom to treatment initiation was virtually identical (2.6 h) for each FFAu quartile (data not shown). Demographic and clinical parameters in this table are representative of the entire TIMI II population.10