. Author manuscript; available in PMC: 2014 Jan 15.

Published in final edited form as: Cancer Prev Res (Phila). 2008 Jul 9;1(4):275–284. doi: 10.1158/1940-6207.CAPR-08-0003

Table 2.

Risk of benign proliferative breast disease in association with dietary modification, overall and by the presence/absence of atypia

	No. of Cases (Annualized %)			P-Value
	Dietary Modification (N=19541)	Comparison (N=29294)	HR (95% CI)^*	Unweighted^*	Weighted^†
Benign proliferative breast disease, all	570 (0.38)	793 (0.35)	1.09 (0.98, 1.23)	0.13	0.18
Benign proliferative breast disease without atypia	477 (0.32)	660 (0.29)	1.10 (0.97, 1.25)	0.12	0.22
Benign proliferative breast disease without atypia (moderately extensive or florid) or with atypia	429 (0.29)	565 (0.25)	1.16 (1.02, 1.33)	0.03	0.05
Atypical hyperplasia	93 (0.06)	133 (0.06)	1.05 (0.79, 1.39)	0.76	0.59

Abbreviations: CI, confidence interval; HR, hazard ratio

Proportional hazards model stratified by age, prior breast disease, and treatment assignment in the HRT and Calcium plus Vitamin D supplement trials.

^†

Weighted log-rank test stratified by age, prior breast disease, and treatment assignment in the HRT trial and adjusted for Calcium plus Vitamin D supplemental trial randomization as a time-dependent covariate. Weights increase linearly from zero at randomization to a maximum of 1 at 10 years.