Table 2. Effect of the essential oil of Hyptis martiusii (EOHM) on gastric secretion parameters basal or stimulated by histamine (20 mg/kg), bethanechol (2.5 mg/kg) or pentagastrin (400 µg/kg) in Wistar rats subjected to pylorus ligature.

Stimulus+treatment	Gastric volume (mL)	pH	Total acidity (mEquiv. [H+]/mL/4 h)
control (not estimulated)	4.4±0.7	1.6±0.2	42.5±11.6
EOHM (not estimulted)	1.8±0.2*	2.4±0.2*	9.2±1.7*
histamine	6.3±0.7	1.5±0.0	52.8±9.9
histamine+ranitidine	2.3±0.3#	2.6±0.1#	2.9±0.6#
histamine+EOHM	4.2±0.2#	1.8±0.1	24.8±2.9#
bethanechol	7.8±0.5	1.5±0.0	52.2±5.4
bethanechol+atropine	2.8±0.2##	2.5±0.2##	6.6±1.5##
bethanechol+EOHM	6.3±0.2	1.6±0.0	38.8±5.3
pentagastrin	7.1±1.4	1.4±0.0	45.0±7.8
pentagastrin+EOHM	3.4±0.2###	1.91±0.1	14.6±3.4###

Values are expressed as mean ± S.E.M. Treatment: control (C, 1% Tween-80 aqueous solution, 0.1 mL/100 g, i.d), EOHM (400 mg/kg, i.d), ranitidine (60 mg/kg, i.d.) and atropine (1 mg/kg, s.c).

p<0.05 vs. control group,

^# p<0.05 vs. histamine group,

^## p<0.05 vs. bethanechol group and

^### p<0.05 vs. pentagastrin group (ANOVA followed by Tukey's test).