Table 3. Effect of oral administration of essential oil of Hyptis martiusii (EOHM) on gastric lesions induced by ethanol in Wistar rats pretreated with L-NAME (N_ω-nitro-L-arginine methyl ester, 70 mg/kg) or NEM (N-ethylmaleimide, 10 mg/kg).

Pretreatment	Treatment (p.o.)	Dose (mg/kg)	Lesion area (mm2)	Inhibition (%)
Saline (i.p.)	control	-	316.9±49.9	-
	carbenoxolone	100	6.6±2.9*	97.9
	EOHM	400	5.8±5.4*	98.1
L-NAME (i.p.)	control	-	655.3±51.2*	-
	carbenoxolone	100	228.5±76.3#	65.1
	EOHM	400	6.5±4.0#	99.0
NEM (i.p.)	control	-	563.0±1.3*	-
	carbenoxolone	100	380.0±42.4	32.5
	EOHM	400	427.6±59.3	24.0

Results are expressed as mean ± S.E.M.

^* p<0.05 compared to saline+control,

^# p<0.05 compared to L-NAME+control (ANOVA followed by Tukey's test).