Table 2. Contingency tables for post-translational modifications, disulphide bonds and electrostatic (h-bonds and salt bridges) interface bonds in mutated residues.

	NO PTM	PTM	NO SS	SS	NO interface bond	interface bond
neutral	2387	25	2409	3	1987	425
driver	3019	69	3082	6	2077	1011
p	0.0007117		0.7398		<2.2e-16

P-values are calculated with a Fisher's test with a two-sided alternative hypothesis.