Table 3. Area propensities of mutations by accessibility.

area and accessibility	normalised frequency of driver/neutral in full set	normalised frequency of driver/neutral in intersection set
interface, <10% accesssible	3.63	11.12
interface, 10–30% accesssible	2.52	4.49
interface, >30% accesssible	1.26	1.52
buried, <10% accesssible	1.79	1.47
surface, 10–30% accesssible	1.55	2.38
surface, >30% accesssible	0.87	0.90

For each area, the percentages denote the relative ASA. Ratios denote the driver/neutral fraction. Values for the set of 23 proteins which contain both neutral and driver mutations is shown on the right.