|
Amino acid biosynthesis
|
| 1 |
B |
hisD
|
1.1.1.23 |
Histidinol dehydrogenase |
L-histidinol+H(2)O+2 NAD(+) < = > L-histidine+2 NADH |
| 2 |
B |
hisG
|
2.4.2.17 |
ATP phosphoribosyltransferase |
1-(5-phospho-D-ribosyl)-ATP+diphosphate < = > ATP+5-phospho-alpha-D-ribose 1-diphosphate |
| 3 |
B |
hisB
|
4.2.1.19 |
Imidazoleglycerol-phosphate dehydratase |
D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate < = > 3-(imidazol-4-yl)-2-oxopropyl phosphate+H(2)O |
| 4 |
B |
hisA
|
5.3.1.16 |
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase |
1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide < = > 5-((5-phospho-1-deoxyribulos-1-ylamino)methylideneamino)-1-(5-phosphoribosyl)imidazole-4-carboxamide |
| 5 |
B,Y |
Meth
|
2.1.1.13 |
5-methyltetrahydrofolate-homocysteine methyltransferase homocysteine-binding subunit |
5-methyltetrahydrofolate+NAD(P)(+) < = > 5,10-methylenetetrahydrofolate+NAD(P)H |
| 6 |
B |
metF
|
1.5.1.20 |
Methylenetetrahydrofolate reductase |
5-methyltetrahydrofolate+L-homocysteine < = > tetrahydrofolate+L-methionine |
| 7 |
F,Y |
metK
|
2.5.1.6 |
Methionine adenosyltransferase |
ATP+L-methionine+H(2)O < = > phosphate+diphosphate+S-adenosyl-L-methionine |
| 8 |
Y |
mtnN
|
3.2.2.16/3.2.2.9 |
Methylthioadenosine nucleosidaseAdenosylhomocysteine nucleosidase |
S-methyl-5′-thioadenosine+H(2)O < = > S-methyl-5-thio-D-ribose+adenineS-adenosyl-L-homocysteine+H(2)O < = > S-(5-deoxy-D-ribos-5-yl)-L-homocysteine+adenine |
| 9 |
B |
trpD
|
2.4.2.18 |
Anthranilate phosphoribosyltransferase |
N-(5-phospho-D-ribosyl)-anthranilate+diphosphate < = > anthranilate+5-phospho-alpha-D-ribose 1-diphosphate |
| 10 |
B |
trpC
|
4.1.1.48 |
Indole-3-glycerol-phosphate synthase |
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate < = > 1-C-(3-indolyl)-glycerol 3-phosphate+CO(2)+H(2)O |
| 11 |
B |
trpF
|
5.3.1.24 |
Phosphoribosylanthranilate isomerase |
N-(5-phospho-beta-D-ribosyl)anthranilate < = > 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate |
| 12 |
B |
dapH
|
2.3.1.89 |
Tetrahydrodipicolinate N-acetyltransferase |
Acetyl-CoA+(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate+H(2)O < = > CoA+L-2-acetamido-6-oxoheptanedioate |
| 13 |
B |
dapB
|
1.3.1.26 |
Dihydrodipicolinate reductase |
(S)-2,3,4,5-tetrahydrodipicolinate+NAD(P)(+) < = > (S)-2,3-dihydrodipicolinate+NAD(P)H |
| 14 |
B |
dapL
|
3.5.1.47 |
N-acetyldiaminopimelate deacetylase |
N-acetyl-LL-2,6-diaminoheptanedioate+H(2)O < = > acetate+LL-2,6-diaminoheptanedioate |
| 15 |
B, Y |
dapF
|
5.1.1.7 |
Diaminopimelate epimerase |
LL-2,6-diaminoheptanedioate < = > meso-diaminoheptanedioate |
| 16 |
B,Y |
lysA
|
4.1.1.20 |
Diaminopimelate decarboxylase |
Meso-2,6-diaminoheptanedioate < = > L-lysine+CO(2) |
| 17 |
B |
aroA/aroH
|
5.4.99.5/2.5.1.54 |
Chorismate mutase/3-deoxy-7-phosphoheptulonate synthase |
Chorismate < = > prephenate Phosphoenolpyruvate+D-erythrose 4-phosphate+H(2)O < = > 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate+phosphate |
| 18 |
Y |
speE
|
2.5.1.16 |
Spermidine synthase |
S-Adenosylmethioninamine+Putrescine < = > 5′-Methylthioadenosine+Spermidine |
| 19 |
F |
gltX1
|
6.1.1.17 |
Glutamate-tRNA ligase |
ATP+L-glutamate+tRNA(Glu) < = > AMP+diphosphate+L-glutamyl-tRNA(Glu) |
| 20 |
Y |
sped
|
4.1.1.50 |
Adenosylmethionine decarboxylase |
S-adenosyl-L-methionine < = > (5-deoxy-5-adenosyl)(3-aminopropyl)-methylsulfonium salt+CO(2) |
| 21 |
B |
aroH
|
2.5.1.54 |
3-deoxy-7-phosphoheptulonate synthase |
Phosphoenolpyruvate+D-erythrose 4-phosphate+H(2)O < = > 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate+phosphate |
| 22 |
B |
aroA
|
5.4.99.5 |
Chorismate mutase |
Chorismate < = > prephenate |
|
Vitamins and cofactors biosynthesis
|
| 23 |
B,Y |
pabC
|
4.1.3.38 |
Aminodeoxychorismate lyase |
4-amino-4-deoxychorismate < = > 4-aminobenzoate+pyruvate |
| 24 |
B |
dfrA
|
1.5.1.3 |
Dihydrofolate reductase |
5,6,7,8-tetrahydrofolate+NADP(+) < = > 7,8-dihydrofolate+NADPH |
| 25 |
B,Y |
folP
|
2.5.1.15 |
Dihydropteroate synthase |
2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate+4-aminobenzoate < = > diphosphate+dihydropteroate |
| 26 |
B,F,Y |
folE
|
3.5.4.16 |
GTP cyclohydrolase I |
GTP+H(2)O < = > formate+2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate |
| 27 |
B,F,Y |
folB
|
4.1.2.25 |
Dihydroneopterin aldolase |
2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine < = > 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine+glycolaldehyde |
| 28 |
B,F,Y |
folC
|
6.3.2.12 |
Dihydrofolate synthase |
ATP+7,8-dihydropteroate+L-glutamate < = > ADP+phosphate+7,8-dihydropteroylglutamate ATP+tetrahydropteroyl-(gamma-Glu)(n)+L-glutamate < = > ADP+phosphate+tetrahydropteroyl-(gamma-Glu)(n+1) |
| 29 |
B,F,Y |
coaE
|
2.7.1.24 |
Dephospho-CoA kinase |
ATP+3′-dephospho-CoA < = > ADP+CoA |
| 30 |
Y |
coaA
|
2.7.1.33 |
Pantothenate kinase |
ATP+(R)-pantothenate < = > ADP+(R)-4′-phosphopantothenate |
| 31 |
B,F,Y |
coaD
|
2.7.7.3 |
Pantetheine-phosphate adenylyltransferase |
ATP+pantetheine 4′-phosphate < = > diphosphate+3′-dephospho-CoA |
| 32 |
B |
nadD
|
2.7.7.18 |
Nicotinate-nucleotide adenylyltransferase |
ATP+nicotinate ribonucleotide < = > diphosphate+deamido-NAD(+) |
| 33 |
F |
nadV
|
2.4.2.12 |
Nicotinamide phosphoribosyltransferase |
Nicotinamide D-ribonucleotide+diphosphate < = > nicotinamide+5-phospho-alpha-D-ribose 1-diphosphate |
| 34 |
F,Y |
ppnK
|
2.7.1.23 |
NAD(+) kinase |
ATP+NAD(+) < = > ADP+NADP(+) |
| 35 |
B,F,Y |
Dfp (coaB and coaC)
|
4.1.1.36/6.3.2.5 |
Phosphopantothenoyl-cysteine decarboxylase Phosphopantothenate-cysteine ligase |
N-((R)-4′-phosphopantothenoyl)-L-cysteine < = > pantotheine 4′-phosphate+CO(2)CTP+(R)-4′-phosphopantothenate+L-cysteine < = > CMP+PPi+N-((R)-4′-phosphopantothenoyl)-L-cysteine |
| 36 |
F |
hemE
|
4.1.1.37 |
Uroporphyrinogen decarboxylase |
Uroporphyrinogen III < = > coproporphyrinogen+4 CO(2) |
| 37 |
F |
hemC
|
2.5.1.61 |
Hydroxymethylbilane synthase |
4 porphobilinogen+H(2)O < = > hydroxymethylbilane+4 NH(3) |
| 38 |
F |
hemF
|
1.3.3.3 |
Coproporphyrinogen oxidase |
Coproporphyrinogen-III+O(2)+2 H(+) < = > protoporphyrinogen-IX+2 CO(2)+2 H(2)O |
| 39 |
F |
hemB
|
4.2.1.24 |
Porphobilinogen synthase |
2 5-aminolevulinate < = > porphobilinogen+2 H(2)O |
| 40 |
F |
hemD
|
4.2.1.75 |
Uroporphyrinogen-III synthase |
Hydroxymethylbilane < = > uroporphyrinogen III+H(2)O |
| 41 |
F |
hemH
|
4.99.1.1 |
Ferrochelatase |
Protoheme+2 H(+) < = > protoporphyrin+Fe(2+) |
| 42 |
F |
hemL
|
5.4.3.8 |
Glutamate-1-semialdehyde 2,1-aminomutase |
(S)-4-amino-5-oxopentanoate < = > 5-aminolevulinate |
| 43 |
F,Y |
ribC (ribF)
|
2.7.1.26/2.7.7.2 |
Riboflavin kinaseFAD synthetase |
ATP+riboflavin < = > ADP+FMNATP+FMN < = > diphosphate+FAD |
| 44 |
Y |
ribA
|
3.5.4.25 |
GTP cyclohydrolase II |
GTP+3 H(2)O < = > formate+2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine+diphosphate |
| 45 |
F,Y |
ribD
|
1.1.1.193/3.5.4.26 |
5-amino-6-(5-phosphoribosylamino)uracil reductase Diaminohydroxyphosphoribosylaminopyrimidine deaminase |
5-amino-6-(5-phospho-D-ribitylamino)uracil+NADP(+) < = > 5-amino-6-(5-phospho-D-ribosylamino)uracil+NADPH2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine+H(2)O < = > 5-amino-6-(5-phosphoribosylamino)uracil+NH(3) |
| 46 |
F |
ubiC
|
4.1.3.40 |
Chorismate lyase |
Chorismate < = > 4-hydroxybenzoate+pyruvate |
|
Non-mevalonate pathway for isoprenoid biosynthesis
|
| 47 |
F |
ispH
|
1.17.1.2 |
4-hydroxy-3-methylbut-2-enyl diphosphate reductase |
Isopentenyl diphosphate+NAD(P)(+)+H(2)O < = > (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate+NAD(P)HDimethylallyl diphosphate+NAD(P)(+)+H(2)O < = > (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate+NAD(P)H |
| 48 |
F |
ispD
|
2.7.7.60 |
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase |
CTP+2-C-methyl-D-erythritol 4-phosphate < = > diphosphate+4-(cytidine 5′-diphospho)-2-C-methyl-D-erythritol |
| 49 |
F |
ispF
|
4.6.1.12 |
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase |
2-phospho-4-(cytidine 5′-diphospho)-2-C-methyl-D-erythritol < = > 2-C-methyl-D-erythritol 2,4-cyclodiphosphate+CMP |
| 50 |
F |
Dxs
|
2.2.1.7 |
1-deoxy-D-xylulose-5-phosphate synthase |
Pyruvate+D-glyceraldehyde 3-phosphate < = > 1-deoxy-D-xylulose 5-phosphate+CO(2) |
| 51 |
F |
uppS
|
2.5.1.31 |
Di-trans,poly-cis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl- diphosphate specific) |
(2E,6E)-farnesyl diphosphate+8 isopentenyl diphosphate < = > 8 diphosphate+di-trans,octa-cis-undecaprenyl diphosphate |
| 52 |
F |
ispE
|
2.7.1.148 |
4-(cytidine 5′-diphospho)-2-C-methyl-D-erythritol kinase |
ATP+4-(cytidine 5′-diphospho)-2-C-methyl-D-erythritol < = > ADP+2-phospho-4-(cytidine 5′-diphospho)-2-C-methyl-D-erythritol |
| 53 |
F |
Dxr
|
1.1.1.267 |
1-deoxy-D-xylulose-5-phosphate reductoisomerase |
2-C-methyl-D-erythritol 4-phosphate+NADP(+) < = > 1-deoxy-D-xylulose 5-phosphate+NADPH |
|
Nucleotides biosynthesis
|
| 54 |
B,F,Y |
Gmk
|
2.7.4.8 |
Guanylate kinase |
ATP+GMP < = > ADP+GDP |
| 55 |
B,F,Y |
Tmk
|
2.7.4.9 |
dTMP kinase |
ATP+dTMP < = > ADP+dTDP |
| 56 |
F |
deoD
|
2.4.2.1 |
Purine-nucleoside phosphorylase |
Purine nucleoside+phosphate < = > purine+alpha-D-ribose 1-phosphate |
|
Fatty acid metabolism
|
| 57 |
B |
fadB
|
1.1.1.35/4.2.1.17/5.3.3.8 |
Enoyl-CoA hydratase Delta(3) -cis-delta(2,3-hydroxyacyl-CoA dehydrogenase -trans-enoyl-CoA isomerase |
S)-3-hydroxyacyl-CoA+NAD(+) < = > 3-oxoacyl-CoA+NADH(3S)-3-hydroxyacyl-CoA < = > trans-2(or 3)-enoyl-CoA+H(2)O(3Z)-dodec-3-enoyl-CoA < = > (2E)-dodec-2-enoyl-CoA |
| 58 |
B |
fadA
|
2.3.1.16 |
3-ketoacyl-CoA thiolase |
Acyl-CoA+acetyl-CoA < = > CoA+3-oxoacyl-CoA |
|
Phospholipid biosynthesis
|
| 59 |
B |
ugtP
|
2.4.1.-2.4.1.157 |
Glucosyldiacylglycerol 6-beta-glucosyltransferase 1,2-diacylglycerol 3-glucosyltransferase |
UDP-glucose+1,2-diacyl-sn-glycerol < = > UDP+3-D-glucosyl-1,2-diacyl-sn-glycerol3-D-Glucosyl-1,2-diacylglycerol+UDP-glucose < = > beta-D-glucosyl-1,6-beta-D-glucosyl-1,3-diacylglycerol+UDP |
| 60 |
B,F |
cdsA
|
2.7.7.41 |
Phosphatidate cytidylyltransferase |
CTP+phosphatidate < = > diphosphate+CDP-diacylglycerol |
| 61 |
B,F,Y |
psd
|
4.1.1.65 |
Phosphatidylserine decarboxylase |
Phosphatidyl-L-serine < = > phosphatidylethanolamine+CO(2) |
| 62 |
Y,F |
pssA
|
2.7.8.8 |
CDP-diacylglycerol–serine O-phosphatidyltransferase |
CDP-diacylglycerol+L-serine < = > CMP+(3-sn-phosphatidyl)-L-serine |
|
Cell wall biosynthesis
|
| 63 |
B,F |
mraY
|
2.7.8.13 |
Phospho-N-acetylmuramoyl-pentapeptide-transferase |
UDP-Mur2Ac (oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)+undecaprenyl phosphate < = > UMP+Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol |
| 64 |
B |
glum
|
2.3.1.157/2.7.7.23 |
Glucosamine-1-phosphate acetyltransferase UDP-N-acetylglucosamine pyrophosphorylase |
Acetyl-CoA+alpha-D-glucosamine 1-phosphate < = > CoA+N-acetyl-alpha-D-glucosamine 1-phosphateUTP+N-acetyl-alpha-D-glucosamine 1-phosphate < = > diphosphate+UDP-N-acetyl-D-glucosamine |
| 65 |
B |
gale
|
5.1.3.2/5.1.3.7 |
UDP-glucose 4-epimerase UDP-N-acetylglucosamine 4-epimerase |
UDP-glucose < = > UDP-galactoseUDP-N-acetyl-D-glucosamine < = > UDP-N-acetyl-D-galactosamine |
| 66 |
B,F |
glmM
|
5.4.2.10 |
Phosphoglucosamine mutase |
Alpha-D-glucosamine 1-phosphate < = > D-glucosamine 6-phosphate |
| 67 |
F,Y |
lpxA
|
2.3.1.129 |
Acyl-[acyl-carrier-protein]–UDP-N-acetylglucosamine O-acyltransferase |
R)-3-hydroxytetradecanoyl-[acyl-carrier-protein]+UDP-N-acetylglucosamine < = > [acyl-carrier-protein]+UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine |
| 68 |
F,Y |
lpxB
|
2.4.1.182 |
Lipid-A-disaccharide synthase |
UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine+2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate < = > UDP+2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate |
| 69 |
F |
murG
|
2.4.1.227 |
Undecaprenyldiphosphomuramoylpentapeptide beta-N- acetylglucosaminyltransferase |
UDP-N-acetylglucosamine+Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol < = > UDP+GlcNAc-(1→4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol |
| 70 |
F |
murB
|
1.1.1.158 |
UDP-N-acetylmuramate dehydrogenase |
UDP-N-acetylmuramate+NADP(+) < = > UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine+NADPH |
| 71 |
F,Y |
kdsA
|
2.5.1.55 |
3-deoxy-8-phosphooctulonate synthase |
Phosphoenolpyruvate+D-arabinose 5-phosphate+H(2)O < = > 2-dehydro-3-deoxy-D-octonate 8-phosphate+phosphate |
| 72 |
F |
murA
|
2.5.1.7 |
UDP-N-acetylglucosamine 1-carboxyvinyltransferase |
Phosphoenolpyruvate+UDP-N-acetyl-D-glucosamine < = > phosphate+UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine |
| 73 |
F,Y |
lpxK
|
2.7.1.130 |
Tetraacyldisaccharide 4′-kinase |
ATP+(2-N,3-O-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl)-(1→6)-(2-N,3-O-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl phosphate) < = > ADP+(2-N,3-O-bis(3-hydroxytetradecanoyl)-4-O-phosphono-beta-D-glucosaminyl)-(1→6)-(2-N,3-O-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl phosphate) |
| 74 |
F,Y |
kdsB
|
2.7.7.38 |
3-deoxy-manno-octulosonate cytidylyltransferase |
CTP+3-deoxy-D-manno-octulosonate < = > diphosphate+CMP-3-deoxy-D-manno-octulosonate |
| 75 |
F |
murF
|
6.3.2.10 |
UDP-N-acetylmuramoyl-tripeptide–D-alanyl-D-alanine ligase |
ATP+UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine+D-alanyl-D-alanine < = > ADP+phosphate+UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine |
| 76 |
F |
murD
|
6.3.2.9 |
UDP-N-acetylmuramoyl-L-alanine–D-glutamate ligase |
ATP+UDP-N-acetylmuramoyl-L-alanine+glutamate < = > ADP+phosphate+UDP-N-acetylmuramoyl-L-alanyl-D-glutamate |
| 77 |
F |
murI
|
5.1.1.3 |
Glutamate racemase |
L-glutamate < = > D-glutamate |
| 78 |
Y |
kdsC
|
3.1.3.45 |
3-deoxy-manno-octulosonate-8-phosphatase |
3-deoxy-D-manno-octulosonate 8-phosphate+H(2)O < = > 3-deoxy-D-manno-octulosonate+phosphate |
| 79 |
Y |
hldD
|
5.1.3.20 |
ADP-glycero-manno-heptose 6-epimerase |
ADP-D-glycero-D-manno-heptose < = > ADP-L-glycero-D-manno-heptose |
|
Carbohydrate metabolism
|
| 80 |
Y |
glgA
|
2.4.1.21 |
Starch synthase |
ADP-glucose+(1,4-alpha-D-glucosyl)(n) < = > ADP+(1,4-alpha-D-glucosyl)(n+1) |
| 81 |
Y |
rhaB
|
2.7.1.5 |
Rhamnulokinase |
ATP+L-rhamnulose < = > ADP+L-rhamnulose 1-phosphate |
| 82 |
Y |
lyx
|
2.7.1.53 |
L-xylulokinase |
ATP+L-xylulose < = > ADP+L-xylulose 5-phosphate |
| 83 |
Y |
ksdD
|
5.3.1.13 |
Arabinose-5-phosphate isomerase |
D-Arabinose 5-phosphate < = > D-Ribulose 5-phosphate |
