Figure 1. Example of experimental beta sheet structure compared to an on-lattice model.

Top: example of a beta sheet in an all-atom structure (1OSP). Note that for clarity only the top sheet of the structure is shown; the hydrophobic downward pointing residues are buried through an another beta sheet. Bottom: example of a designed protein that can fold into its native structure (shown) containing a beta sheet. Note that the designed structure was not explicitly modelled to resemble the experimental structure, but is the result of a stochastic design algorithm (see Methods). Yellow, grey, red and blue residues indicate hydrophobic, polar, negative and positive amino acids respectively.