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. 2014 Jan 15;9(1):e85461. doi: 10.1371/journal.pone.0085461

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© 2014 Ge et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A,B) Bone marrow progenitors were defined among lineage negative cells as hematopoietic stem cells (HSC, CD117⁺Sca⁺), myeloid progenitors (MP, CD117⁺Sca⁻), common myeloid progenitors (CMP, CD34⁺Fcγr⁻ among MP) and granulocyte macrophage progenitors (GMP, CD34⁺Fcγr⁺ among MP). To assess the role of the IL-17 receptor on a cell specific level, the proportion of wt and Il17ra^-/- cells at each stage was analyzed in mixed bone marrow chimeric mice (B, n = 10 from 3 independent transplantations). (C,D) Similarly bone marrow CD11b⁺CD115⁺ monocytes were analyzed for genotype (C) and Gr1^high proportion (D) in wt and Il17ra^-/- cells (n = 10 from 3 independent transplantations, paired t-test).