Figure 8. In peritonitis, Il17ra^-/- monocyte recruitment is sustained, but macrophage phenotype changed.

(A,B) Peritonitis was induced in mixed bone marrow chimeric wt/Il17ra^-/- mice. Peripheral blood (at start and end of the experiment) and peritoneal neutrophils (PMN, CD11b⁺CD115⁻Gr1^high, A) and monocytes (CD11b⁺CD115⁺, B) were analyzed by flow cytometry after 10 h (n = 4, Bonferroni after ANOVA). (C) At day 3, intraperitoneal myeloid CD11b⁺ cells were analyzed and compared to peripheral blood monocytes at start and end of the experiment (n = 4–6, 2 independent transplantations, Bonferroni after ANOVA). (D) CD11c expression on wt and Il17ra^-/- myeloid (CD11b⁺) cells was compared in lung, spleen, resting and inflamed peritoneal cavity of mixed bone marrow chimeric wt/Il17ra^-/- mice (n = 4–8, paired t-tests).