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. 2014 Jan 15;9(1):e85461. doi: 10.1371/journal.pone.0085461

Figure 9. Reduced renal macrophage generation in response to urethral obstruction in the absence of IL-17 receptor.

Figure 9

Renal fibrosis was induced by unilateral ureteral obstruction (UUO) in mixed wt/Il17ra-/- bone marrow chimeric mice. Myeloid cell accumulation in the obstructed kidney was assessed for wt and Il17ra-/- cells in identical environments (A,B) Total CD11b+ myeloid cell infiltration to the kidney (A, ctrl = contralateral kidney, UUO = obstructed kidney) and their genotype (B, #indicates significance level against expected 50% wt ratio, *between UUO and ctrl) was determined. (C,D) For assessment of differentiation, renal myeloid cell CD11c, F4/80 (C) and Gr1 (D) surface marker expression was tested (n = 6 from 2 independent transplantations, paired t-tests). (E) Renal myeloid cell proliferation was assessed 24 h after a single injection of BrdU (n = 4).