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. 2014 Jan 15;9(1):e85461. doi: 10.1371/journal.pone.0085461

Figure 10. Decreased renal fibrosis in the absence of IL-17 receptor on myeloid cells.

Figure 10

Unilateral ureteral obstruction was performed in wt and Il17ra-/- bone marrow chimeric mice. (A–C) Histologic assessment of fibrosis was conducted after Masson's trichrome (A), Sirius red (B, birefringent sirius red positive fibrotic tissue area analyzed from n = 5/group from 2 independent transplantations, 40× original magnification) and αSMA- immunofluorescent staining (C, n = 7 from 2 independent transplantations, scale bar = 100 µm) on day 7. (D) mRNA expression of collagen I, fibrinonectin and CTGF was assessed in obstructed kidneys by quantitative PCR (day seven, n = 3, t-tests).