Figure 5.

CabPK-activated I_Trans-LTS is sensitive to changes in extracellular Ca²⁺ and extracellular Na⁺. A, Superimposed sweeps of current recordings from the LG neuron, recorded in TEVC with TEACl/CsCl-filled electrodes, during depolarizing steps to different membrane potentials (−65 to −35 mV) from a holding voltage of −80 mV, during CabPK application in control, reduced Ca²⁺ (0.1× normal), and post-reduced Ca²⁺ solutions. Note that in the reduced Ca²⁺ condition I_Trans-LTS is not evident, nor is I_Trans-LTF. B, Same protocol as in A, except that in the experimental condition (middle trace) extracellular Na⁺ was replaced with an equimolar concentration of NMDG⁺. Note the absence of I_Trans-LTS in the presence of NMDG⁺.