Table 2.
Demographics and clinical parameters of the patients studied for plasma antibodies against oxidized lipid epitopes
| Variables | Bleeding status | P-value | |
|---|---|---|---|
| |
No SAH |
Prior SAH |
|
| (n = 41) |
(n = 84) |
||
| A. Patients |
|
|
|
| Age (years) |
54y. (28–70) |
55.5y. (11–84) |
0.298 |
| Gender (females) |
71% (30/42) |
71% (60/84) |
1.00 |
| Patients with multiple sIAs (≥2) |
36% (15/42) |
46% (39/84) |
0.340 |
| Patients with more than one known aneurysmal SAH |
- |
4% (3/84) |
NA |
| Severity of the SAH (Hunt&Hess-grading) |
|
|
NA |
| 0 (no bleeding) |
42 |
- |
|
| 1 (asymptomatic or mild headache / nuchal rigidity) |
- |
7% (6/84) |
|
| 2 (moderate headache / nuchal rigidity) |
- |
31% (26/84) |
|
| 3 (drowsiness/confusion, mild neurological deficit) |
- |
27% (23/84) |
|
| 4 (stupor, moderate-severe hemiparesis) |
- |
18% (15/84) |
|
| 5 (coma or decerebrate posturing) |
- |
8% (7/84) |
|
| Hunt & Hess for the prior bleeding not known |
|
7% (6/84) |
|
| Known familial background |
29% (12/42) |
7% (6/84) |
<0.001* |
| Smoking |
|
|
<0.001 # |
| Current |
50% (21/42) |
42% (35/84) |
|
| Ex-smoker |
14% (6/42) |
4% (3/84) |
|
| Never smoked |
36% (15/42) |
21% (18/84) |
|
| Status not known |
0 |
32% (27/84) |
|
| Hypertension | 36% (15/42) | 40% (34/84) | 0.799 |
Median and range are given for continuous variables, proportions for categorical variables. Mann–Whitney U-test was used for continous and Fisher’s Exact test for categorical variables. NA, Not applicable.
* The percentage of unknown family histories is very high, especially in the PRIOR SAH group (76%, 64/84) making conclusions of the familial background unreliable.
#Although the difference of smoking habits between patients with unruptured sIAs and a history of aneurysmal SAH was highly significant, it is important to notice that in the SAH group the smoking history of 32% of patients was not unknown, which may significantly affect the result.