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. 2013 Oct 2;1:63. doi: 10.1186/2051-5960-1-63

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Copyright © 2013 Gabrielli et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fetal inflammatory response in CMV-positive inner ears. A) CD8 immunohistochemistry showing numerous CD8-positive lymphocytes in the epithelial layers of the stria vascularis and within the Reissner’s membrane. Lymphocytic infiltrate was mainly found in proximity to cytomegalic cells. B) Granzyme B immunohistochemistry in the stria vascularis: most of the lymphocytes close to CMV infected cells (small arrows) were activated expressing Granzyme B (big arrow). C) CD8 immunohistochemistry showing CD8-positive lymphocytes along the cochlear nerve fibers. D) CD8 immunohistochemistry showing CD8-positive lymphocytes within the spiral ganglion.