Table 1.
Cure rates in C57BL/6 wild-type (WT), CYP 2D knock-out, and humanized/CYP 2D6 knock-in mice 31 days post-inoculation with Plasmodium berghei in the absence or presence of NPC-1161B and tafenoquine
| NCP-1161B | |||
|---|---|---|---|
|
i |
Mouse strain |
1161B Dose |
Cure |
| |
WT |
- |
0/5 |
| |
WT |
ED
100
|
5/5 |
| |
2DKO |
- |
0/5 |
| |
2DKO |
ED
100
|
0/5 |
| |
2DKO/2D6KI |
ED
100
|
0/5 |
|
Tafenoquine (TQ) | |||
|
ii |
Mouse strain |
TQ Dose |
Cure |
| |
WT |
- |
0/5 |
| |
WT |
ED
100
|
5/5 |
| |
2DKO |
- |
0/5 |
| |
2DKO |
ED
100
|
0/5 |
| |
2DKO/2D6KI |
ED
100
|
0/5 |
| 2DKO/2D6KI | 2 × ED 100 | 4/5 | |
A cure is indicated if there was no detectable parasite burden in blood measurements after 31 days post-inoculation.