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. 2013 Jul 25;1:40. doi: 10.1186/2051-5960-1-40

Figure 4.

Figure 4

Neuropathology of perilesional areas. Gemistocytes (arrows in a-c) are present and the expression of (a) AQP4 (AQP4, scale bar = 50 μm), (b) AQP1 (AQP1, scale bar = 50 μm), and (c) GFAP (GFAP, scale bar = 50 μm) is increased at the lesions’ borders. (d) Vacuolated white matter (HE, scale bar = 250 μm) with the appearance of (e) intramyelinic edema (inset shows higher magnification) is a common feature of nonlesional pontine white matter tracts with preserved myelin (PLP, scale bar = 250 μm, inset scale bar = 25 μm), (f) normal AQP4 (AQP4, scale bar = 250 μm), (g) normal AQP1 (AQP1, scale bar = 250 μm), (h) normal GFAP expression (GFAP, scale bar = 250 μm), and (i) microglial infiltration (KiM1P, scale bar = 250 μm); (j) Normal appearing gray and (k) white matter show profound microglial activation with rare clusters of small macrophages (KiM1P, scale bar = 50 μm); Red ischemic neurons (l) and ballooned neurons (m) are present in the normal appearing gray matter (HE, scale bar = 50 μm).

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