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. 2014 Jan 11;14:14. doi: 10.1186/1472-6882-14-14

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Copyright © 2014 Song et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Temporal expression of genes and microRNAs after SST treatment in primary mouse hepatocytes. (A) Approximately 1100 differentially expressed genes with a fold ratio greater than 2 or less than 0.5 for at least one sample are clustered hierarchically. Sub-cluster 1 and Sub-cluster 2 indicate the two sub-clusters. Columns represent individual samples and rows represent individual genes. The expression ratio is represented in colors from red (i.e., high) to green (i.e., low), as indicated by the scale bar. (B) Temporally altered genes were identified by the Short Time-series Expression Miner (STEM) analysis and classified in two patterns (false discovery rate [FDR] less than 0.001). The temporal up-pattern comprises 463 genes and the temporal down-pattern comprises 177 genes. (C) Approximately 540 microRNAs with a minimum fold ratio of 1.5 in at least one sample are clustered hierarchically.