Table 1.
GPCR expression levels by linkage analysis clusters, compared to normal cerebella
| |
Cluster “A” |
Cluster “B” |
Cluster “C” |
Cluster “D” |
Cluster E” |
|||||
|---|---|---|---|---|---|---|---|---|---|---|
| |
(n = 7) |
(n = 4) |
(n = 10) |
(n = 4) |
(n = 14) |
|||||
| Fold change | p-value | Fold change | p-value | Fold change | p-value | Fold change | p-value | Fold change | p-value | |
| FZD2 |
25 |
0.01 |
27 |
0.04 |
16 |
0.01 |
45 |
0.01 |
4.5 |
0.05 |
| RPLP0 |
15 |
0.01 |
7.8 |
0.32 |
9.8 |
0.01 |
28 |
0.01 |
2.9 |
0.19 |
| EDG4 |
25 |
0.01 |
22 |
0.04 |
22 |
0.01 |
20 |
0.03 |
7.8 |
0.04 |
| PTGER4 |
14 |
0.01 |
2.0 |
0.43 |
5.7 |
0.01 |
2.9 |
0.30 |
1.1 |
0.90 |
| GPR126 |
17 |
0.01 |
13 |
0.21 |
15 |
0.01 |
0.67 |
0.76 |
6.1 |
0.08 |
| OR2C3 |
0.035 |
0.01 |
0.026 |
0.29 |
0.0076 |
0.01 |
0.12 |
0.49 |
1.1 |
0.89 |
| FKSG83 |
0.010 |
0.01 |
0.037 |
0.22 |
0.30 |
0.26 |
0.61 |
0.69 |
2.7 |
0.31 |
| F2R |
73 |
0.01 |
54 |
0.04 |
55 |
0.02 |
29 |
0.03 |
15 |
0.03 |
| DRD2 |
75 |
0.01 |
24 |
0.10 |
17 |
0.02 |
19 |
0.04 |
4.9 |
0.13 |
| GPR142 |
0.078 |
0.60 |
undetectable |
5.E-03 |
0.51 |
0.81 |
1.0 |
0.99 |
0.23 |
0.52 |
| OPRM1 |
0.57 |
0.74 |
0.0028 |
0.22 |
0.0063 |
0.01 |
0.0032 |
0.23 |
0.00050 |
3.E-03 |
| GPR147 |
0.059 |
0.15 |
0.011 |
0.29 |
0.0056 |
0.01 |
0.035 |
0.10 |
0.00050 |
5.E-04 |
| GPR62 |
2.2 |
0.30 |
7.3 |
0.07 |
14 |
0.01 |
10 |
0.15 |
3.1 |
0.08 |
| GPR153 |
3.3 |
0.10 |
8.7 |
0.21 |
8.5 |
0.01 |
0.50 |
0.24 |
3.0 |
0.04 |
| PPYR1 |
0.59 |
0.63 |
0.033 |
0.21 |
0.030 |
0.01 |
0.47 |
0.37 |
1.2 |
0.82 |
| EDG8 |
0.053 |
0.10 |
0.080 |
0.29 |
0.11 |
0.01 |
0.15 |
0.37 |
0.50 |
0.19 |
| GPR160 |
2.4 |
0.19 |
5.9 |
0.22 |
12 |
0.01 |
1.2 |
0.90 |
1.4 |
0.61 |
| SSTR3 |
0.40 |
0.61 |
0.13 |
0.49 |
0.068 |
0.01 |
0.72 |
0.62 |
0.99 |
0.99 |
| GPR10 |
0.15 |
0.19 |
0.11 |
0.38 |
0.082 |
0.01 |
0.23 |
0.20 |
0.58 |
0.36 |
| EDG7 |
0.42 |
0.48 |
0.12 |
0.56 |
0.12 |
0.03 |
0.0079 |
0.01 |
0.032 |
1.E-03 |
| GRM6 |
19 |
0.22 |
326 |
0.29 |
248 |
0.02 |
1539 |
0.01 |
79 |
0.01 |
| CCKBR |
0.28 |
0.60 |
0.12 |
0.29 |
0.039 |
0.03 |
0.0028 |
0.01 |
0.010 |
0.01 |
| OPRK1 |
0.29 |
0.49 |
1.0 |
1.0 |
0.21 |
0.20 |
0.0027 |
0.01 |
0.046 |
0.03 |
| CHRM4 |
19 |
0.55 |
5.1 |
0.23 |
4.8 |
0.11 |
74 |
0.01 |
3.3 |
0.21 |
| OPRD1 |
11.8 |
0.29 |
3.3 |
0.76 |
1.9 |
0.40 |
344 |
0.01 |
0.85 |
0.88 |
| LGR5 |
0.50 |
0.71 |
0.83 |
0.95 |
0.45 |
0.55 |
117 |
0.01 |
0.22 |
0.17 |
| GPR123 |
0.048 |
0.19 |
0.034 |
0.23 |
0.031 |
0.02 |
0.0041 |
0.15 |
0.0016 |
4.E-04 |
| NTSR2 |
0.023 |
0.03 |
0.030 |
0.23 |
0.080 |
0.03 |
0.0030 |
0.04 |
0.0056 |
5.E-04 |
| TRBV5 |
0.083 |
0.14 |
0.077 |
0.22 |
0.10 |
0.08 |
2.0 |
0.79 |
0.0051 |
3.E-03 |
| ADORA1 |
0.83 |
0.91 |
0.28 |
0.32 |
0.14 |
0.14 |
3.0 |
0.33 |
0.019 |
3.E-03 |
| ADRA1A |
0.27 |
0.38 |
0.066 |
0.23 |
0.024 |
0.03 |
0.0082 |
0.19 |
0.0088 |
0.01 |
| GRM4 |
0.13 |
0.30 |
0.11 |
0.32 |
0.037 |
0.06 |
0.0043 |
0.03 |
0.0048 |
0.01 |
| HTR5A |
0.074 |
0.17 |
0.12 |
0.29 |
0.17 |
0.15 |
0.0091 |
0.03 |
0.017 |
0.01 |
| GPR84 |
0.20 |
0.19 |
0.39 |
0.54 |
0.10 |
0.05 |
0.045 |
0.04 |
0.043 |
0.01 |
| GPR39 |
0.11 |
0.20 |
0.0068 |
0.05 |
0.015 |
0.02 |
0.0041 |
0.03 |
0.0058 |
0.01 |
| GPR77 |
1.0 |
0.99 |
0.47 |
0.54 |
0.85 |
0.85 |
0.14 |
0.51 |
0.041 |
0.01 |
| GPR37L1 |
0.049 |
0.19 |
0.057 |
0.22 |
0.080 |
0.11 |
0.0054 |
0.19 |
0.0058 |
0.01 |
| GPR63 |
1.5 |
0.77 |
0.18 |
0.53 |
0.075 |
0.10 |
1.4 |
0.82 |
0.012 |
0.01 |
| GPR75 |
0.48 |
0.43 |
0.15 |
0.21 |
0.22 |
0.11 |
0.13 |
0.06 |
0.029 |
0.01 |
| OR2A4 |
0.51 |
0.50 |
5.7 |
0.22 |
3.7 |
0.08 |
2.1 |
0.51 |
3.3 |
0.01 |
| CD97 | 4.6 | 0.12 | 1.4 | 0.68 | 1.8 | 0.11 | 1.5 | 0.67 | 0.27 | 0.01 |
* Fold-change <1 indicates decreased expression compared to normal cerebellum; all fold-change levels rounded to two significant digits. Significant fold-changes (p ≤ 0.01) indicated indicated in bold.