Table 4.
Odds ratios for CMH in sex stratified adjusted* analyses
|
Males |
LSC n = 227 |
PLuSS n = 183 |
Combined n = 410 |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Exposure variable | OR | (95 % CL) | p value | OR | (95 % CL) | p value | OR | (95 % CL) | p value |
|
Total methylation |
1.23 |
(1.07, 1.41) |
0.004** |
1.28 |
(1.07, 1.54) |
0.008 |
1.23 |
(1.11, 1.37) |
<.0001** |
|
SULF2 |
2.72 |
(1.51, 4.91) |
0.001** |
2.97 |
(1.48, 5.95) |
0.002** |
2.73 |
(1.75, 4.25) |
<.0001** |
|
p16 |
2.08 |
(1.01, 4.28) |
0.048 |
1.66 |
(0.71, 3.89) |
0.246 |
1.88 |
(1.09, 3.23) |
0.023 |
|
JPH3 |
2.64 |
(1.43, 4.87) |
0.002** |
2.70 |
(0.96, 7.59) |
0.059 |
2.66 |
(1.58, 4.48) |
<.0001** |
|
PCDH20 |
1.68 |
(0.94, 2.98) |
0.079 |
2.29 |
(1.15, 4.53) |
0.018 |
1.89 |
(1.22, 2.93) |
0.004** |
|
Females |
LSC n = 673 |
PLuSS n = 307 |
Combined n = 980 |
||||||
|
Exposure variable |
OR |
(95 % CL) |
p value |
OR |
(95 % CL) |
p value |
OR |
(95 % CL) |
p value |
|
Total methylation |
1.04 |
(0.96, 1.14) |
0.324 |
1.08 |
(0.93, 1.25) |
0.322 |
1.05 |
(0.98, 1.13) |
0.188 |
|
SULF2 |
1.41 |
(0.97, 2.05) |
0.074 |
1.72 |
(0.96, 3.07) |
0.066 |
1.47 |
(1.07, 2.01) |
0.016 |
|
p16 |
1.25 |
(0.79, 1.99) |
0.342 |
1.76 |
(0.91, 3.40) |
0.091 |
1.41 |
(0.97, 2.05) |
0.073 |
|
JPH3 |
1.07 |
(0.71, 1.62) |
0.748 |
1.20 |
(0.42, 3.39) |
0.736 |
1.10 |
(0.75, 1.62) |
0.634 |
| PCDH20 | 1.33 | (0.92, 1.93) | 0.126 | 1.35 | (0.72, 2.52) | 0.346 | 1.34 | (0.97, 1.83) | 0.073 |
Each row represents a separate adjusted model.
*Additional adjustors include age, education, COPD, current smoking, pack years, and cohort (for combined analysis); CMH as outcome.
**Bonferroni adjusted significance threshold is p < 0.0042.