Table 5.
Odds ratios for CMH in adjusted* analyses of current and former smokers
| |
LSC former smokers n = 406 |
PLuSS former smokers n = 155 |
Combined former smokers n = 561 |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Exposure variable | OR | (95 % CL) | p value | OR | (95 % CL) | p value | OR | (95 % CL) | p value |
|
Total methylation |
1.13 |
(1.01, 1.26) |
0.034 |
1.36 |
(1.10, 1.67) |
0.004** |
1.18 |
(1.07, 1.30) |
0.001** |
|
SULF2 |
1.96 |
(1.17, 3.29) |
0.011 |
3.64 |
(1.51, 8.77) |
0.004** |
2.30 |
(1.47, 3.59) |
<.0001** |
|
p16 |
2.06 |
(1.13, 3.76) |
0.018 |
1.53 |
(0.59, 3.95) |
0.377 |
1.92 |
(1.16, 3.17) |
0.012 |
|
JPH3 |
1.79 |
(1.04, 3.09) |
0.037 |
2.76 |
(0.99, 7.71) |
0.053 |
2.02 |
(1.25, 3.26) |
0.004** |
|
PCDH20 |
1.9 |
(1.13, 3.18) |
0.015 |
1.15 |
(0.46, 2.90) |
0.768 |
1.67 |
(1.07, 2.61) |
0.024 |
| |
LSC current smokers n = 494 |
PLuSS current smokers n = 335 |
Combined current smokers n = 829 |
||||||
|
Exposure variable |
OR |
(95 % CL) |
p value |
OR |
(95 % CL) |
p value |
OR |
(95 % CL) |
p value |
|
Total methylation |
1.07 |
(0.97, 1.17) |
0.18 |
1.07 |
(0.94, 1.23) |
0.303 |
1.07 |
(0.99, 1.15) |
0.106 |
|
SULF2 |
1.53 |
(1.03, 2.28) |
0.036 |
1.82 |
(1.09, 3.04) |
0.022 |
1.60 |
(1.17, 2.19) |
0.003** |
|
p16 |
1.15 |
(0.70, 1.89) |
0.578 |
1.83 |
(0.98, 3.41) |
0.057 |
1.39 |
(0.95, 2.05) |
0.094 |
|
JPH3 |
1.3 |
(0.84, 1.99) |
0.237 |
1.16 |
(0.42, 3.19) |
0.779 |
1.29 |
(0.87, 1.91) |
0.200 |
| PCDH20 | 1.17 | (0.79, 1.72) | 0.433 | 1.98 | (1.16, 3.36) | 0.012 | 1.39 | (1.02, 1.90) | 0.039 |
Each row represents a separate adjusted model.
*Additional adjustors include age, sex, education, COPD, pack years, and cohort (for combined analysis); CMH as outcome.
**Bonferroni adjusted significance threshold is p < 0.0042.