Table 2.
Significant and trend-level comparisons between control (N = 11) and high-cortisol depressed (N = 7) subjects.
| Measurement
|
Day1
|
Control Group (N = 11)
|
Depressed High Cortisol (N = 7)
|
P values
|
|||
|---|---|---|---|---|---|---|---|
| Mean ± SEM
|
Median (range)
|
Mean ± SEM
|
Median (range)
|
Unpaired t -test
|
Kruskal-Wallis
|
||
| Pulsatile ACTH sec | 1 | 221 ± 21 | 187 (140–334) | 296 ± 36 | 265 (170–421) | 0.089 | 0.077 |
| Basal cortisol secr | 1 | 17 ± 4.7 | 13 (0.68–51) | 33 ± 6.7 | 28 (15–59) | 0.031 | 0.052 |
| Pulsatile cortisol secr | 1 | 66 ± 6.6 | 63 (37–115) | 79 ± 5.0 | 77 (61–96) | 0.082 | 0.077 |
| Cortisol burst mode | 2 | 27 ± 4.2 | 23 (11–58) | 16 ± 4.4 | 9.6 (6.2–37) | 0.042 | 0.051 |
| Cortisol ApEn | 1 | 1.2458 ± 0.0217 | 1.2343 (1.1283–1.3492) | 1.3986 ± 0.0381 | 1.4249 (1.2448–1.5316) | 0.005 | 0.004 |
| ACTH-cortisol X-ApEn | 1 | 1.6875 ± 0.0274 | 1.7022 (1.5058–1.8162) | 1.8155 ± 0.0292 | 1.8361 (1.6967–1.9043) | 0.006 | 0.013 |
1
Day 1 = Placebo; Day 2 = Metyrapone
Unpaired parametric and nonparametric P values
Trend was defined as 0.05 < P < 0.10.
The mode is the time delay from secretory-burst onset to maximum.
Units are ng/L/10 hr for pulsatile ACTH secretion, μg/dL/10 hr for basal and pulsatile cortisol secretion, and min for cortisol burst mode. ApEn and cross-ApEn are unitless.