Table 3.
Univariate analyses of ferritin levels at entry after natural log (Ln) transformation according to diseases, age, sex, race, and genotype at entry
| Variables |
Continuous ferritin levels |
Dichotomized ferritin levels |
||
|---|---|---|---|---|
| Mean ± SD ng/ml | P value* | Odds ratio [95% CI] | P value** | |
|
OA patients (
N
= 127) |
59.1 ± 114.9 |
0.334 |
2.21 [0.71–8.25] |
0.151 |
|
Healthy controls (
N
= 20) |
37.07 ± 22.98 |
|
|
|
|
Age >56 years (
N
= 109)
¶
|
62.5 ± 121.7 |
0.0186 |
2.31 [0.94– 6.15] |
0.050 |
|
Age ≤56 years (
N
= 38) |
35.6 ± 22.8 |
|
|
|
|
Female (
N
= 89) |
51.94 ± 133.5 |
0.0006 |
2.8 [1.34– 5.9] |
0.0034 |
|
Male (
N
= 58) |
62.49 ± 43.7 |
|
|
|
|
White (
N
= 97) |
57.7 ± 128.9 |
|
0.78 [0.37–1.7] |
0.595 |
|
Asian (
N
= 13) |
48.52 ± 33.9 |
0.727 |
|
|
|
African American (
N
= 37) |
54.4 ± 44.8 |
0.411 |
|
|
|
Genotype: |
|
|
|
|
| +/+ (
N
= 110) |
47.4 ± 38.7 |
Reference |
|
|
| H63D/+ (
N
= 23) |
43.0 ± 37.1 |
0.529*** |
1.2 [0.44–3.38] |
0.646 |
| C282Y/+ (
N
= 7) |
44.2 ± 34.8 |
0.951*** |
0.65 [0.06– 4.19] |
0.709 |
| H63D/H63D (
N
= 2) |
21.3 ± 11.6 |
0.401*** |
|
NA |
| C282Y/H63D (
N
= 2) |
75.3 ± 6.6 |
0.210*** |
|
NA |
| C282Y/C282Y ( N = 3) | 513.6 ± 646.9 | 0.00006*** | NA | |
Data are presented as mean ± standard deviation (SD).
P values refer to difference between two groups as derived from:
*t test on log-transformed ferritin.
**Chi-square test.
¶Cut-off based on mean age of healthy controls.
***+/+ (wild type) versus mutation.