Table 4.

Univariate and multivariate linear regression analysis of the role of age, sex, BMI, geographic origin, and the CD4 counts or HIV-1 RNA levels in insulin resistance (HOMA-IR) in the HIV-infected patients included in the metabolic sub-study of the ANRS COPANA cohort. The multivariate analysis included either the CD4 count or the HIV viral load (see Methods).

	Univariate		Multivariate
Characteristics	beta coefficient	p value	beta coefficient	p value	beta coefficient	p value
Age*	+0.34	0.003	+0.26	0.01	+0.34	0.001
Female sex	+0.45	0.06	+0.04	0.88	+0.14	0.55
BMI**	+0.07	0.002	+0.07	0.003	+0.05	0.02
Geographic origin	+0.42	0.06	−0.12	0.59	+0.03	0.89
CD4 count (/mm3)
>500	Reference		Reference
]350–500]	+0.09	0.72	+0.07	0.76
]200–350]	+0.11	0.71	+0.11	0.67
≤200	+1.11	0.0002	+0.90	0.001
HIV-RNA (log copies/mL)
≤3.70	Reference				Reference
]3.70–4.35]	−0.02	0.95			+0.41	0.11
]4.35–4.86]	−0.21	0.48			+0.16	0.54
>4.86	−0.23	0.44			+0.18	0.48

^*per a 10-year increase;

^**per a 1-kg/m² increase.

Females were compared to males, and patients of Sub-Saharan Africa origin to other patients.

HIV-RNA levels were categorized according to the 25th, 50th, and 75th percentiles.