Increased symptom burden and/or decreased quality of life
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Significant decrease in functional capacity
Worsening heart failure prompting hospitalization, particularly if recurrent57
Serial increases of maintenance diuretic dose
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Symptomatic hypotension, azotemia, or refractory fluid retention necessitating neurohormonal medication underdosing or withdrawal58
First or recurrent ICD shock for VT/VF59
Initiation of intravenous inotropic support
Consideration of renal replacement therapy
Other important comorbidities: new cancer, etc
Major “life events”: death of a spouse