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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Int J Hyperthermia. 2013 Jul 17;29(5):464–473. doi: 10.3109/02656736.2013.807440

Figure 4. Collaborative intersection between thermal therapy and IL-6 in the tumor microenvironment.

Figure 4

(A) Thermal therapy tips the balance of IL-6 activity in the tumor microenvironment from a tumor-promoting inflammatory role to an anti-tumorigenic role supporting T cell-mediated tumor immunity. (B) Outstanding questions remain regarding which chemokine/chemokine receptor interactions (inset) mediate CD8+ T cell trafficking at the vascular interface during heat therapy and whether clinical responses to preconditioning regimens are predicated on the presence of immunosuppressive cell subsets (inset) within the tumor microenvironment.