Table 1.
Specification of chemical structure and anti-HCV activities of triterpenoid saponin extracts of Platycodon grandiflorum on NS5B RdRp and NS3/4A protease functions.
| Compounds | Aglycone | Composition of sugar | HCV enzyme (IC50, μg/mL) | ||
|---|---|---|---|---|---|
| C-3 | C-28 | HCV NS5B |
HCV NS3/4A |
||
| PG-extract | — | — | — | 67 | >100 |
| PGSM | — | — | — | 5 | >100 |
| Platycodin D | Platycodigenin | Glc- | Api-(1→3)-Xyl-(1→4)-Rha-(1→2)-Ara- | 5 | >100 |
| Platycodin D2 | Glc-(1→3)-Glc- | Api-(1→3)-Xyl-(1→4)-Rha-(1→2)-Ara- | 6 | >100 | |
| Platycodin D3 | Glc-(1→6)-Glc- | Api-(1→3)-Xyl-(1→4)-Rha-(1→2)-Ara- | 8 | >100 | |
| Deapioplatycodin D | Glc- | Xyl-(1→4)-Rha-(1→2)-Ara- | 7 | >100 | |
| Deapioplatycodin D2 | Glc-(1→3)-Glc- | Xyl-(1→4)-Rha-(1→2)-Ara- | 10 | >100 | |
| Platyconic acid A | Platycogenic acid A | Glc- | Api-(1→3)-Xyl-(1→4)-Rha-(1→2)-Ara- | 15 | >100 |