Table 2.
Inhibitory effects of triterpenoid saponins on HCV replication in HCV replicon cells and in HCVcc-infected cells.
Compounds | Inhibition of HCV RNA replication (EC50, μg/mL) | Cytotoxicity (CC50, μg/mL) | |
---|---|---|---|
CON1 (genotype 1b) | JHF-1 (genotype 2a) | ||
PG-extract | 35 | >100 | |
PGSM | 0.78 | 8 | 25 |
Platycodin D | 0.35 | 3 | 25 |
Platycodin D2 | 1.05 | 12 | 25 |
Platycodin D3 | 2.33 | 27 | 100 |
Deapioplatycodin D | 1.2 | 7 | 25 |
Deapioplatycodin D2 | 0.89 | 8 | 100 |
Platyconic acid A | 2.45 | 22 | 100 |