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. Author manuscript; available in PMC: 2014 Jan 16.
Published in final edited form as: J Med Chem. 2010 Oct 14;53(19):7146–7155. doi: 10.1021/jm101144f

Table 9.

Mouse PK data of 26a

Route Cmax (ng/mL) Tmax (h) AUC (h*ng/mL) T1/2 (h) MRT (h) CL (mL/min/Kg) Vss (L/Kg) F (%)
IV 2757 ND 720 0.5 0.43 23.0 0.59 ND
PO 223 0.25 396 0.79 1.51 ND ND 5.49
IP 5121 0.08 5718 4.52 ND ND ND ND
a

C57BL/6 male mouse was dosed at 1 mg/Kg for the intravenous (IV), 10 mg/Kg for the oral (PO) and 10 mg for the intraperitineal (IP) studies. I. formulation used 10% N-Methyl pyrrolidone (NMP) and 50% polyethylene glycol (PEG-200) in water. P.O. formulation used 0.5% w/v NaCMC with 0.1% w/v Tween-80. IP administration formulation was 10% v/v dimethylacetimate (DMA); 20% v/v polyethylene glycol (PEG-200); 20% v/v PG in water