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. Author manuscript; available in PMC: 2014 Jan 16.
Published in final edited form as: Physiol Rev. 2012 Jul;92(3):967–1003. doi: 10.1152/physrev.00030.2011

FIGURE 2.

FIGURE 2

Multiple HIF-1α isoforms are generated as a result of alternative splicing and alternative promoter utilization. A: alternative splicing of the primary RNA transcript generates mRNAs encoding six different isoforms with the indicated domain composition. B: alternative promoter utilization results in three alternative first exons (Ex 1.1, 1.2, and 1.3) and alternative NH2-terminal amino acid sequences with the translation initiation codon (ATG) present either in the first exon (Ex 1.1, 1.3) or second exon (Ex 1.2).