. Author manuscript; available in PMC: 2014 Jan 16.

Published in final edited form as: Physiol Rev. 2012 Jul;92(3):967–1003. doi: 10.1152/physrev.00030.2011

Table 1.

Hypoxia-inducible gene expression mediated by factors other than HIF-1 or HIF-2

Factor	Target Gene(s)	Tissue/Cells	Reference Nos.
AP-1	Heme oxygenase 1	Pulmonary artery ECs	110
	Tyrosine hydroxylase	PC-12 cells	243
	Interleukin-8 (IL-8)	Ovarian carcinoma cells	358
ATF-4	Carbonic anhydrase 9	Mouse embryo fibroblasts	337
	LAMP3	Human tumor cell lines	236
CREB	Amphiregulin	T84 intestinal epithelial cells	244
	IL-8, MHC-II, TNF-α	T84 intestinal epithelial cells	327
EGR-1	Tissue factor, ICAM-1	Vasculature and mononuclear cells	361-363
	IL-1 β, IP-10, MIP-2,
	MCP-1, PAI-1, RANTES
	VEGF
	EGFR	Human osteosarcoma cells	242
HMG-I(Y)	COX-2	Human umbilical vein ECs	140
NF-IL6	IL-6	Vascular ECs	364
		Cardiac myocytes	218
	TNF receptor 2	NIH 3T3 cells	112
NF-_kB	BCL-X	Brain	98
	TNF-α	J774.1 macrophage cells	44
	COX-2	Human umbilical vein ECs	289
	IL-6	Cardiac myocytes	218
	IL-8	Ovarian carcinoma cells	358
	IL-8, MMP-9, VEGF	Prostate cancer cells	126
PUR_α	CD11b, CD11c	U937 cells	163
Sp1	COX-2	Human umbilical vein ECs	359
Sp1/Sp3	PKM, β-enolase	C2C12 myocytes	72
Unknown	GADD153, p27	Mouse embryonic stem cells	40
	IAP-2	Mouse embryonic stem cells	74
	Ornithine decarboxylase	Mouse embryonic stem cells	135
	p27	Mouse embryo fibroblasts	96
	VEGF	Human colon cancer cell lines	231

See text for definitions.