Table 1.
Results of large scale HTS. Curve classes are defined in Inglese et al.23. Compounds in class 1.1 and 2.1 have high efficacy with either complete (1.1) or partial (2.1) dose response curves and are typically considered the most promising compounds from the screen.
| Activity | Distribution | Curve Classification | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1.1 | 1.2 | 1.3 | 1.4 | 2.1 | 2.2 | 2.3 | 2.4 | 3 | 4 | 5 | ||
| Activation | Cmpd No | 10 | 0 | 0 | 0 | 119 | 74 | 0 | 36 | 115 | ||
| % library | 0.003% | 0.00% | 0.00% | 0.00% | 0.04% | 0.02% | 0.00% | 0.01% | 0.03% | 329717 | 52 | |
| Inhibition | Cmpd No | 3 | 0 | 0 | 0 | 7 | 497 | 0 | 735 | 3330 | 98.51% | 0.02% |
| % library | 0.001% | 0.00% | 0.00% | 0.00% | 0.002% | 0.15% | 0.00% | 0.22% | 0.99% | |||