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Analytical approach for the quantitation of endogenous and exogenous formaldehyde DNA adducts. The left panel outlines the methodology for the determination of the DNA adducts. The upper right panel shows the formation of the endogenous (upper route) and exogenous (lower route) N2-OHMedG adducts. The lower right panel shows the representative LC-MS/MS chromatograms of endogenous, exogenous and isotope-labeled internal standard.
