Table 1.
Formaldehyde-induced N2-hydroxy-methyl-dG monoadducts in rats exposed to 10 ppm formaldehyde for 1 day or 5 days.
| Exposure Period | Tissues | N2-HOCH2-dG (adducts/107 dG) | N2-HOCH2-dA (adducts/107 dA) | ||
|---|---|---|---|---|---|
| Exogenous | Endogenous | Exogenous | Endogenous | ||
| 1 day | Nose | 1.28 ± 0.49 | 2.63 ± 0.73 | nd | 3.95 ± 0.26 |
| Lung | nd* | 2.39 ± 0.16 | nd | 2.62 ± 0.24 | |
| Liver | nd | 2.66 ± 0.53 | nd | 2.62 ± 0.46 | |
| Spleen | nd | 2.35 ± 0.31 | nd | 1.85 ± 0.19 | |
| Bone Marrow | nd | 1.05 ± 0.14 | nd | 2.95 ± 1.32 | |
| Thymus | nd | 2.19 ± 0.36 | nd | 2.98 ± 1.11 | |
| Mononuclear WBC | nd | 1.28 ± 0.38 | nd | 3.80 ± 0.29 | |
| 5 day | Nose | 2.43 ± 0.78 | 2.84 ± 1.13 | nd | 3.61 ± 0.95 |
| Lung | nd | 2.61 ± 0.35 | nd | 2.47 ± 0.55 | |
| Liver | nd | 3.24 ± 0.42 | nd | 2.87 ± 0.65 | |
| Spleen | nd | 2.35 ± 0.59 | nd | 2.23 ± 0.89 | |
| Bone Marrow | nd | 1.17 ± 0.35 | nd | 2.99 ± 0.08 | |
| Thymus | nd | 1.99 ± 0.30 | nd | 2.48 ± 0.11 | |
| Mononuclear WBC | nd | 1.10 ± 0.28 | nd | 3.66 ± 0.78 | |
Adapted from Lu, Collins, et al. (2010)
*
nd: not detected