Table 5.

Quantitative analysis of CK2 protein steady-state levels from immunoblots of schedule response PC3-LN4 orthotopic xenograft tumors

Treatment (schedule response)	Cumulative dose	CK2α nuclear matrix	CK2α′ nuclear matrix	CK2β nuclear matrix	NF-jB p65 nuclear matrix	AKT cytosol	AKT p-Ser473 cytosol
bs-AS-CK2 1 × 66 μg/kg	66 μg/kg	0.28 ± 0.06	0.53 ± 0.09	0.89 ± 0.41	0.93 ± 0.11	1.18 ± 0.10	1.01 ± 0.16
bs-AS-CK2 2 × 33 μg/kg q1d	66 μg/kg	0.49 ± 0.06	0.53 ± 0.04	0.72 ± 0.22	0.77 ± 0.08	1.00 ± 0.17	0.89 ± 0.13
bs-AS-CK2 2 × 33 μg/kg q4d	66 μg/kg	0.54 ± 0.16	0.75 ± 0.13	0.77 ± 0.33	0.74 ± 0.20	0.27 ± 0.10	0.40 ± 0.04
bs-AS-CK2 4 × 16.5 μg/kg q1d	66 μg/kg	0.31 ± 0.08	0.45 ± 0.05	0.41 ± 0.10	0.63 ± 0.11	0.49 ± 0.16	0.61 ± 0.15
AS-GAPDH 1 × 66 μg/kg	66 μg/kg	1	1	1	1	1	1