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. 2014 Jan 16;10(1):e1003426. doi: 10.1371/journal.pcbi.1003426

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(A) PEX5 (green oval) associated with cargo (orange square) binds to available binding sites on a peroxisomal importomer (blue irregular shape) at a rate . There are binding sites per importomer; here we illustrate . (B) If unoccupied, the RING complex site is immediately occupied by another PEX5 on the importomer. (C) The RING complex (purple rectangle) will ubiquitinate an associated PEX5 at rate . We generally allow only one ubiquitinated PEX5 per importomer. For (A), (B), and (C) the AAA complex is shown, and will participate in PEX5 export as described in Fig. 2.

Inline graphic — (A) PEX5 (green oval) associated with cargo (orange square) binds to available binding sites on a peroxisomal importomer (blue irregular shape) at a rate . There are binding sites per importomer; here we illustrate . (B) If unoccupied, the RING complex site is immediately occupied by another PEX5 on the importomer. (C) The RING complex (purple rectangle) will ubiquitinate an associated PEX5 at rate . We generally allow only one ubiquitinated PEX5 per importomer. For (A), (B), and (C) the AAA complex is shown, and will participate in PEX5 export as described in Fig. 2.