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. 2014 Jan 16;10(1):e1004108. doi: 10.1371/journal.pgen.1004108

Figure 6. An expanded network of proteins is required for SP to bind sperm and to be utilized in mated females.

Figure 6

(A) The SP network. Colors of protein names indicate predicted protein functional classes: red = protease or protease homolog; green = cysteine-rich secretory protein (CRISP); dark blue = C-type lectin; light blue oval = SP; purple = unknown function. Boxes indicate proteins discovered by ERC; other proteins were described previously [21], [28]. Intrepid acts upstream of SP-SPR signaling, but at present we cannot position it further. (B) New members of the SP network function at steps consistent with their signals of ERC. New network proteins are shown in rows; known network proteins are shown in columns. Each cell indicates the empirical p-value associated with the protein's pair ERC value. P-values less than 0.05 are shaded in red; more intense shading indicates a stronger correlation.