Table 2. Relative levels of phosphorylation of individual EGFR P-sites.
P-site | |||||||||
992 | 1045 | 1068 | 1086 | 1101 | 1114 | 1148 | 1173 | Citation | |
in vitro study | +++ | +++ | +++ | [57] | |||||
+++* | +++ | +++* | +++* | [58] | |||||
+++* | ++ | +++* | +++* | [5] | |||||
+ | ++* | +++* | +++* | +++* | +++* | [59] | |||
cultured cell study | ++ | ++ | +++ | [57] | |||||
− | + | +++ | +++ | +++ | +++ | +++ | [35] | ||
NA | +++ | +++ | NA | NA | NA | +++ | +** | [44] | |
+++ | ++ | + | ++ | + | +++ | [34] |
A survey of studies of EGFR phosphorylation site usage indicating relative phosphorylation of individual P-sites on a scale from +, ++ to +++ (−, phosphorylation negligible or not resolvable; NA, not analyzed).
implied in the cited study.
greatly enhanced by HER2 expression.