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. 2014 Jan 16;10(1):e1004100. doi: 10.1371/journal.pgen.1004100

Table 1. Neuronal targets of SKN-1 identified by RNA sequencing.

Sequence Gene wdr-23 RPKM Rescue RPKM q value Function WWTDTCAT Consensus
Neurotransmitter receptor/channels
F53E10.2 acr-17 2.72 0.88 0.044 AcetylCholine Receptor 2
F59B1.9 acr-23 2.34 0.39 0.007 AcetylCholine Receptor 2
Y39A3B.5 ckr-2 4.93 2.14 0.038 CholecystoKinin Receptor homolog 0
C14F11.3 lite-1 14.73 2.73 0.000 high-energy LIghT unrEsponsive 3
F07F6.6 nmr-1 1.81 0.33 0.000 NMDA class glutamate receptor 0
F22B7.7 twk-7 10.86 4.14 0.032 TWiK family of potassium channels 1
K03B8.9 deg-3 5.28 1.76 0.011 DEGeneration of certain neurons 3
Neuropeptide related
F01D4.4 egl-21 167.13 78.59 0.000 EGg Laying defective 1
F23B2.5 flp-1 91.90 40.17 0.003 FMRF-Like Peptide 3
F33D4.3 flp-13 45.08 17.05 0.028 FMRF-Like Peptide 2
Y37D8A.15 flp-14 61.85 29.67 0.038 FMRF-Like Peptide 0
Y48D7A.2 flp-18 68.87 29.16 0.019 FMRF-Like Peptide 1
C03G5.7 flp-5 81.68 30.02 0.009 FMRF-Like Peptide 1
F31F6.4 flp-8 52.69 19.64 0.008 FMRF-Like Peptide 0
C36H8.3 flp-9 94.50 39.40 0.007 FMRF-Like Peptide 3
ZK84.7 ins-20 115.05 3.18 0.000 INSulin related 3
C51E3.7 egl-3 181.88 71.98 0.000 Proprotein convertase 3
B0244.2 ida-1 79.04 36.08 0.002 related to Islet cell autoantigen 0
T03D8.3 sbt-1 178.81 86.52 0.009 7B2 prohormone convertase chaperone 2
Presynaptic structure/function
C23H4.1 cab-1 159.33 82.03 0.000 C-terminus-of-AEX-Binding protein 2
F33E2.2 dlk-1 37.71 24.67 0.049 DAP Like Kinase 0
C40C9.5 nlg-1 14.06 5.68 0.001 NeuroLiGin family 5
R153.1 pde-4 48.15 30.29 0.036 PhosphoDiEsterase 1
ZK524.2 unc-13 19.60 10.98 0.002 UNCoordinated 2
Signal transduction
B0412.2 daf-7 12.43 4.12 0.019 abnormal DAuer Formation 2
T13C5.1 daf-9 3.28 0.83 0.005 abnormal DAuer Formation 2
Y73F8A.1 pkd-2 3.76 0.68 0.000 human PKD2 related 2
C02C6.2 olrn-1 14.24 6.06 0.015 Olfactory LeaRNing defective 2
T13H10.1 kin-5 3.88 0.89 0.017 protein KINase 0
ZK265.5 sre-23 3.80 0.86 0.029 Serpentine Receptor, class E 5
Other
F26D12.1 fkh-7 59.08 29.71 0.004 ForKHead transcription factor family 0
R06F6.6 ceh-62 18.94 7.35 0.038 Uncharacterized homeobox protein 1
D1046.5 tpra-1 46.32 19.46 0.000 UPF0359 membrane protein 2
F26A3.5 9.39 1.94 0.007 1
F59C6.2 4.49 0.49 0.001 2
Y32H12A.1 10.57 0.86 0.000 0
ZC21.3 35.45 15.18 0.013 0

RNAseq list of genes with neuronal expression patterns according to WormMart WS220 that were rescued by Psnb-1::wdr-23a in wdr-23 mutants. Functions identified by DAVID. Consensus indicates the number of SKN-1 binding sites (WWTDTCAT) in promoter fragments within 1 kb of transcriptional start site as evaluated by RSAT.