Table 1. Neuronal targets of SKN-1 identified by RNA sequencing.
| Sequence | Gene | wdr-23 RPKM | Rescue RPKM | q value | Function | WWTDTCAT Consensus |
| Neurotransmitter receptor/channels | ||||||
| F53E10.2 | acr-17 | 2.72 | 0.88 | 0.044 | AcetylCholine Receptor | 2 |
| F59B1.9 | acr-23 | 2.34 | 0.39 | 0.007 | AcetylCholine Receptor | 2 |
| Y39A3B.5 | ckr-2 | 4.93 | 2.14 | 0.038 | CholecystoKinin Receptor homolog | 0 |
| C14F11.3 | lite-1 | 14.73 | 2.73 | 0.000 | high-energy LIghT unrEsponsive | 3 |
| F07F6.6 | nmr-1 | 1.81 | 0.33 | 0.000 | NMDA class glutamate receptor | 0 |
| F22B7.7 | twk-7 | 10.86 | 4.14 | 0.032 | TWiK family of potassium channels | 1 |
| K03B8.9 | deg-3 | 5.28 | 1.76 | 0.011 | DEGeneration of certain neurons | 3 |
| Neuropeptide related | ||||||
| F01D4.4 | egl-21 | 167.13 | 78.59 | 0.000 | EGg Laying defective | 1 |
| F23B2.5 | flp-1 | 91.90 | 40.17 | 0.003 | FMRF-Like Peptide | 3 |
| F33D4.3 | flp-13 | 45.08 | 17.05 | 0.028 | FMRF-Like Peptide | 2 |
| Y37D8A.15 | flp-14 | 61.85 | 29.67 | 0.038 | FMRF-Like Peptide | 0 |
| Y48D7A.2 | flp-18 | 68.87 | 29.16 | 0.019 | FMRF-Like Peptide | 1 |
| C03G5.7 | flp-5 | 81.68 | 30.02 | 0.009 | FMRF-Like Peptide | 1 |
| F31F6.4 | flp-8 | 52.69 | 19.64 | 0.008 | FMRF-Like Peptide | 0 |
| C36H8.3 | flp-9 | 94.50 | 39.40 | 0.007 | FMRF-Like Peptide | 3 |
| ZK84.7 | ins-20 | 115.05 | 3.18 | 0.000 | INSulin related | 3 |
| C51E3.7 | egl-3 | 181.88 | 71.98 | 0.000 | Proprotein convertase | 3 |
| B0244.2 | ida-1 | 79.04 | 36.08 | 0.002 | related to Islet cell autoantigen | 0 |
| T03D8.3 | sbt-1 | 178.81 | 86.52 | 0.009 | 7B2 prohormone convertase chaperone | 2 |
| Presynaptic structure/function | ||||||
| C23H4.1 | cab-1 | 159.33 | 82.03 | 0.000 | C-terminus-of-AEX-Binding protein | 2 |
| F33E2.2 | dlk-1 | 37.71 | 24.67 | 0.049 | DAP Like Kinase | 0 |
| C40C9.5 | nlg-1 | 14.06 | 5.68 | 0.001 | NeuroLiGin family | 5 |
| R153.1 | pde-4 | 48.15 | 30.29 | 0.036 | PhosphoDiEsterase | 1 |
| ZK524.2 | unc-13 | 19.60 | 10.98 | 0.002 | UNCoordinated | 2 |
| Signal transduction | ||||||
| B0412.2 | daf-7 | 12.43 | 4.12 | 0.019 | abnormal DAuer Formation | 2 |
| T13C5.1 | daf-9 | 3.28 | 0.83 | 0.005 | abnormal DAuer Formation | 2 |
| Y73F8A.1 | pkd-2 | 3.76 | 0.68 | 0.000 | human PKD2 related | 2 |
| C02C6.2 | olrn-1 | 14.24 | 6.06 | 0.015 | Olfactory LeaRNing defective | 2 |
| T13H10.1 | kin-5 | 3.88 | 0.89 | 0.017 | protein KINase | 0 |
| ZK265.5 | sre-23 | 3.80 | 0.86 | 0.029 | Serpentine Receptor, class E | 5 |
| Other | ||||||
| F26D12.1 | fkh-7 | 59.08 | 29.71 | 0.004 | ForKHead transcription factor family | 0 |
| R06F6.6 | ceh-62 | 18.94 | 7.35 | 0.038 | Uncharacterized homeobox protein | 1 |
| D1046.5 | tpra-1 | 46.32 | 19.46 | 0.000 | UPF0359 membrane protein | 2 |
| F26A3.5 | 9.39 | 1.94 | 0.007 | 1 | ||
| F59C6.2 | 4.49 | 0.49 | 0.001 | 2 | ||
| Y32H12A.1 | 10.57 | 0.86 | 0.000 | 0 | ||
| ZC21.3 | 35.45 | 15.18 | 0.013 | 0 | ||
RNAseq list of genes with neuronal expression patterns according to WormMart WS220 that were rescued by Psnb-1::wdr-23a in wdr-23 mutants. Functions identified by DAVID. Consensus indicates the number of SKN-1 binding sites (WWTDTCAT) in promoter fragments within 1 kb of transcriptional start site as evaluated by RSAT.