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. 2014 Jan 16;9(1):e85888. doi: 10.1371/journal.pone.0085888

Figure 4. Induction of food allergy in athymic nude mice.

Figure 4

A: The occurrence of allergic diarrhea in wild-type (WT) FA mice and nude FA mice after each oral OVA challenge is shown (n = 5 mice per group). B: The level of OVA-specific IgE in the plasma of WT naïve mice, WT FA mice, nude naïve mice and nude FA mice is shown. The level of OVA-specific IgE in the plasma was determined using an ELISA kit. **P<0.01 vs. WT naïve mice, ††P<0.01 vs. WT FA mice (n = 3–5 mice per group). C: The level of mMCP-1 in the plasma of WT naïve mice, WT FA mice, nude naïve mice and nude FA mice is shown. The level of mMCP-1 in the plasma was determined using an ELISA kit. *P<0.05 vs. WT naïve mice, ††P<0.01 vs. WT FA mice (n = 3–5 mice per group). D: The proximal colon of WT FA mice and nude FA mice after the 6th oral OVA challenge was stained with anti-mMCP-1 antibodies. Scale bars represent 200 µm.