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. 2014 Jan 16;10(1):e1003885. doi: 10.1371/journal.ppat.1003885

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© 2014 Ataide et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) PBMCs derived from P. vivax malaria patients and healthy donors were lysed, cross-linked by treatment with disuccinimidyl suberate [70], and ASC oligomerization assessed by Western blot analysis. PBMCs from a healthy donor stimulated with LPS and nigericin were used as positive control. . (B) NLRP3, NLRP12 and AIM2 containing inflammasomes (specks) in monocytes from P. vivax malaria patients were visualized in a confocal microscope. (C) The bar graphs show the frequency of specks in monocytes derived from P. vivax malaria patients. We saw no specks on cells from healthy donors or cells from malaria patients incubated with the secondary antibody only. See also Figure S6.