Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Jan 16;10(1):e1003878. doi: 10.1371/journal.ppat.1003878

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2014 Patocka et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

Summary of mechanisms by which serotonin can stimulate worm movement. The results suggest that serotonin works through its Sm5HTR receptor to stimulate interneuronal and/or neuromuscular signaling, indirectly increasing contractility of the musculature. Serotonin may also have direct effects on the muscles but it is unclear if those effects are mediated by Sm5HTR or a different receptor. An additional mechanism by which serotonin may control movement is through modulation of sensory neuronal circuits, where Sm5HTR is abundantly expressed. These could play an important role in mediating locomotory responses to host-derived signals, for example chemotactic responses or other types of host-parasite interaction.