Figure 1. Schematic diagram of LIF signaling pathways. LIF binds to LIFR, which leads to the heterodimerization of LIFR and gp130. This is followed by the activation of JAK-STAT3, PI3K/Akt, and Erk1/2 signaling pathways. The activated STAT3 leads to increased expression of SOCS3, which serves as a negative feedback signal to LIF stimulated activation of STAT3 and Erk1/2.