Figure 2. CLEC9A direct apoptotic material toward storage compartments. Apoptotic cells are taken up by dendritic cells (DCs). Upon engagement of C-type lectin domain family 9, member A (CLEC9A) on the DC surface, apoptotic cells are directed to RAB5A⁺RAB27A⁺ endosomes. RAB27A rapidly recruits NOX2 to the endosomal membrane, hence preventing an excessive acidification of the maturing endosome and allow for the establishment of a storage compartment. In the absence of CLEC9A the endosomal cargo is quickly dispatcher to lysosomes and fully degraded. CLEC9A thus facilitates the slow degradation and prolonged storage of apoptotic material, a mechanism that may account for the ability of CLEC9A to enhance the cross-presentation of cell-associated antigens.