Figure 3. Type I interferon signaling influences antigen persistence within dendritic cells. Plasmacytoid DCs (pDC) and perhaps also conventional DCs (cDC) produce interferon α (IFNα) upon the recognition of apoptotic cells. The exposure of cDCs to IFNα results in¹ the upregulation of pro-survival factors such as BCL-2 and BCL-X_L;² the prolonged storage of apoptotic material in intracellular compartments; and³ the localization of MHC class I molecules to storage compartments.