Table 2.
Vaccine efficacy evaluation with respect to viremia
| Group | No. dams, (N) | Viremia positive dams
|
Viremia negative dams
|
% viremia+ (100 x nv+/N) | Odds ratio (exact 95% CI) | VE, % | p-value | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. (nv+) | GM, 105 CMV DNA copies/mL | Litters
|
No. | Litters
|
||||||||
| All live pups (≥1 CMV+ pup) | ≥1 dead pup (≥1 CMV+ pup) | All live pups (≥1 CMV+ pup) | ≥1 dead pup (≥1 CMV+ pup) | |||||||||
| control | 14 | 13 | 6.8 | 5 (1) | 8 (8) | 1 | 0 (0) | 1 (1) | 93 | - | - | - |
|
| ||||||||||||
| gB/FA | 10 | 7 | 0.9 | 3 (3) | 4 (4) | 3 | 2 (1) | 1 (1) | 70 | 0.180 (0.016–2.064) | 25 | 0.272 |
|
| ||||||||||||
| gB/AS02V | 10 | 3 | 1.7 | 2 (2) | 1 (1) | 7 | 5 (5) | 2 (1) | 30 | 0.033 (0.0007–0.478) | 68 | 0.002a |
|
| ||||||||||||
| gB/AS01B | 9 | 1 | 0.9 | 0 (0) | 1 (1) | 8 | 5 (4) | 3 (2) | 11 | 0.0096 (0.0002–0.235) | 88 | <0.001a |
a
Significantly different from control (Fisher exact test with a Bonferroni correction for multiple comparisons, such that α=0.05/3=0.017).
No., number. N, total number of dams/group; nv+, number of viremia-positive dams/group; nv−, number of viremia-negative dams/group, ≥1 CMV+ pup, at least one CMV-positive pup/litter/group; viremia+, viremia-positive; GM, geometric mean; CI, confidence interval;. VE, vaccine efficacy.