WT mice and KHK-A/C KO mice were given ad libitum LFD, HFD or HFHSD for 15 weeks (n = 7-8). (a) Growth curves of WT mice fed LFD, HFD or HFHSD. (b) Growth curves of KHK-A/C KO mice fed LFD, HFD or HFHSD. (c-e) Growth curves of WT mice and KHK-A/C KO mice fed LFD (c), HFD (d) or HFHSD (e). *P < 0.05, **P < 0.01, ***P < 0.001 vs. respective LFD group. #P < 0.05 vs. WT fed HFD.